HRID5899

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)C1Cc2c(ccc(OC)c2OCc2ccc(C(=O)OC)cc2)CN1C(=O)C(c1ccccc1)c1ccccc1

HCID15296730

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(c1OCc1ccc(C(=O)O)cc1)CC(C(=O)O)N(C(=O)C(c1ccccc1)c1ccccc1)C2

HCID15296726

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

2 次

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

A solution of 1.10 g (0.0019 mole) of the diester from Example 32 in 100 mL of methanol and 15 mL of 2N sodium hydroxide is heated to the boiling point, allowing the methanol to distill off. After 1 hour (pot temperature =90° C.), 1N hydrochloric acid (35 mL) is added to precipitate a gum. On addition of 10 mL of ether, crystals develop; wt. 0.84 g. Recrystallization from ethyl acetate petroleum ether gives pure product; mp 190°-192° C.

WORKUP

后处理

distillationto distill off
additionAfter 1 hour (pot temperature =90° C.), 1N hydrochloric acid (35 mL) is added
customto precipitate a gum
additionOn addition of 10 mL of ether, crystals
customRecrystallization from ethyl acetate petroleum ether
customgives pure product

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7bee3f2deba042d7930137633227fc6b
来源数据集: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05246943
来源说明: uspto-grants-1993_09

反应 SMILES

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][O:12][C:13]2[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[C:19]3[C:14]=2[CH2:15][CH:16]([C:40]([O:42]CC)=[O:41])[N:17]([C:25](=[O:39])[CH:26]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:18]3)=[CH:7][CH:6]=1)([O:3]C)=[O:2]>CO.[OH-].[Na+]>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][O:12][C:13]2[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[C:19]3[C:14]=2[CH2:15][CH:16]([C:40]([OH:42])=[O:41])[N:17]([C:25](=[O:39])[CH:26]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:18]3)=[CH:7][CH:6]=1)([OH:3])=[O:2]