Isocyanate → 1-(3-Chloro-4-fluorophenyl)-3-(4-{[2-({[(3-chloro-4-fluorophenyl)amino]carbonyl}amino)imidazo[1,2-b]pyridazin-6-yl]ethynyl}phenyl)urea

Participants

Reaction Steps

The compound of Example 15 was by preparing 6-[(4-aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-amine as in Example 20, followed by a procedure similar to Example 3 using 2-chloro-1-fluoro-4-isocyanatobenzene as the isocyanate (see also Schemes 1, 2, and 9).

Provenance & Evidence