(1S,4S)-2,5-Diazabicyclo[2.2.1]heptane → HCID 68432570, compound

HRID 589920Notes

Reaction equation

HRID 589920 reaction equation
[C@H]12C[C@H](NC1)CN2.[ClH:8].C[CH:10]1[CH2:15][NH:14][CH2:13][CH:12]([CH3:16])[N:11]1[C:17]1[N:22]=[CH:21][CH:20]=[CH:19][N:18]=1>>[ClH:8].[N:22]1[CH:21]=[CH:20][CH:19]=[N:18][C:17]=1[N:11]1[CH2:10][C@@H:15]2[CH2:16][C@H:12]1[CH2:13][NH:14]2

Participants

3

Reactant 2

HCID 11908852(1S,4S)-2,5-Diazabicyclo[2.2.1]heptaneHCID 684321412-(2,6-Dimethylpiperazin-1-yl)pyrimidine hydrochloride

Product 1

HCID 68432570HCID 68432570, compound

Procedure

Using (1S,4S)-2,5-diazabicyclo[2.2.1]heptane, reactions similar to those in Example 1 (2), (3) were successively performed to give (1S,4S)-2-pyrimidin-2-yl-2,5-diazabicyclo[2.2.1]heptane hydrochloride, then reactions similar to those in Example 1 (4) were performed to give the title compound (201 mg).

Sources & evidence

ORD record
ord-9b482195f70248c8b4732f0edf4e59eb
Source dataset
uspto-grants-2016_01
Patent number
US09233969B2

Reaction notes

Loading…