N-cyclobutylsulfamoyl chloride → N-cyclobutyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide

Participants

Reaction Steps

To 4-(4,7-diaza-spiro[2.5]oct-7-yl)-7H-pyrrolo[2,3-d]pyrimidine (6.55 mmol) (intermediate 21) in dry pyridine (25 mL) was added N-cyclobutylsulfamoyl chloride (7.86 mmol) (Intermediate 29). The reaction mixture was stirred at rt for 16 h. After evaporation of the solvent in vacuo the crude mixture was purified by flash chromatography on silica using heptane→MeOH:EtOAc affording the title compound as white crystals.

Provenance & Evidence