Water → HCID 57410093, compound

Participants

Reaction Steps

4-(4-Phenethylsulfamoyl-4,7-diaza-spiro[2.5]oct-7-yl)-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester (intermediate 6) (0.1 mmol) was dissolved in dry DMF (0.5 mL) and added Cs2CO3 (0.12 mmol) and bromo-ethane (0.12 mmol). Stirred at rt for 16 h and then added H2O (2 mL). Extracted with EtOAc (3×2 mL) and the combined organic phases were concentrated in vacuo. The residual oil was treated with TFA (1 mL) at rt for 3 h. The pure compound was obtained by standard preparative HPLC purification of the reaction mixture.

Provenance & Evidence