Trifluoroacetic acid → HCID 57410697, compound

Participants

Reaction Steps

4-{4-[2-(Tetrahydro-pyran-2-yloxy)-ethylsulfamoyl]-4,7-diaza-spiro[2.5]oct-7-yl}-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester (intermediate 16) was treated with TFA (1 mL) at rt for 1 h. The crude reaction mixture was concentrated in vacuo and redissolved in DMSO (0.5 mL). The pure compound was obtained by standard preparative HPLC purification of the reaction mixture.

Provenance & Evidence