HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 589977Generated: October 27, 2026
3-Hydroxypropionic acid → N-[[1-(3-hydroxypropanoyl)pyrrolidin-3-yl]methyl]-N-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide
https://huagongshe.com/reaction/589977
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Hydroxypropionic acid | HCID 68152 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | PyBroP | HCID 2733179 | — |
| Reactant | N-methyl-N-(pyrrolidin-3-ylmethyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide | HCID 57410097 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-[[1-(3-hydroxypropanoyl)pyrrolidin-3-yl]methyl]-N-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide | HCID 57411295 | — |
Reaction Steps
N-methyl-N-(pyrrolidin-3-ylmethyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5,8-diazaspiro[2.5]octane-8-sulfonamide (intermediate 25) (0.042 mmol) was dissolved in dry DMSO (0.5 mL), added DIPEA (0.25 mL), 3-hydroxypropanoic acid (0.050 mmol) and Pybrop (0.050 mmol) then stirred at 40° C. for 1 h. The pure compound was obtained by standard preparative HPLC purification of the reaction mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09233964B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-bd92120cc44c44c4af45ba052783ba1e |
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| Source note | uspto-grants-2016_01 |
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