Triethylamine → HCID 68295985, compound

Participants

Reaction Steps

Intermediate 4 (0.071 mmol) was dissolved in dry DCM (1 mL) and added commercial available cyclopentanecarbonyl chloride (0.085 mmol) and Et3N (0.21 mmol). Stirred at rt for 1 h and then at 40° C. for 1.5 h. More 1,1-dioxothiolane-3-carbonyl chloride was added (2×0.107 mmol) with 1 h in between each portion. After being stirred at 40° C. for 1 h the reaction mixture was concentrated in vacuo, added 2,2,2-trifluoroethanol (1 mL) and stirred at 60° C. for 16 h. The pure compound was obtained by standard preparative HPLC purification of the reaction mixture.

Provenance & Evidence