Isopropyl iodide → HCID 67517948, compound

Participants

Reaction Steps

To a solution of 3-(methylsulfanyl)-1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-6,7-dihydrothieno[3,4-c]pyridin-4(5H)-one (30 mg, 0.076 mmol) in DMF (0.7 mL) at 0° C. was added NaH (1.8 mg, 0.076 mmol). After 10 min, 2-iodopropane (13 mg, 0.076 mmol) was added and the reaction mixture was stirred at rt overnight, The resulting mixture was concentrated and purified directly by silica gel chromatography (gradient elution, 0-40% EtOAc/hexanes) to afford the title compound. LRMS (ESI) m/z 438.0 [(M+H)+; calcd for C20H31N3O2S2Si: 438].

Provenance & Evidence