Potassium Carbonate → HCID 67517961, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(methylsulfanyl)-1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-3-yl)-6,7-dihydrothieno[3,4-c]pyridin-4(5H)-one (Example 3) (20 mg, 0.051 mmol) in DMF (120 μL) at rt was added iodobenzene (21 mg, 0.101 mmol), K2CO3 (7 mg, 0.051 mmol) and CuI (1.0 mg, 0.0051 mmol). The reaction mixture was heated at 150° C. for 72 h. The resulting mixture was concentrated and purified directly by silica gel chromatography (gradient elution, 0-50% EtOAc/hexanes) to afford the title compound. LRMS (ESI) m/z 471.9 [(M+H)+; calcd for C23H29N3O2S2Si: 472].

Provenance & Evidence