HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → 3-(Cyclohexylamino)-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | 3-Bromo-1-indanone | HCID 11745912 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-(Cyclohexylamino)-2,3-dihydro-1H-inden-1-one | HCID 42614802 | 84% |
Reaction Steps
3-Bromo-2,3-dihydro-1H-inden-1-one (100 mg, 475 μmol) and cyclohexylamine (94 mg, 951 μmol) were dissolved in 2 mL of dry benzene and stirred under N2 until precipitation ceased (˜15 min) The cyclohexylamine.HBr was removed by filtration. The filtrate was applied to a flash SiO2 column that was developed with 8:1 hexanes-EtOAc to give the title compound as a clear oil (91 mg, 84% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439877B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-53548c7e825e4ed685f012ad3877349d |
| Source note | uspto-grants-2016_09 |