反应详情

4-(1-Oxoindan-2-ylidenemethyl)benzonitrile (2.18 g, 8.9 mmol) was dissolved in carbon tetrachloride (40 mL). N-bromosuccinimide (1.58 g, 8.9 mmol) and benzoyl peroxide (100 mg) were added in one portion. Reaction mixture was reflux for 9 h, cooled down; precipitate was filtered off and washed with diethyl ether (10×30 mL) for removal of N-hydroxysuccinimide Precipitate was dried under vacuum, provided pure 15a.

1. customReaction mixture
2. temperaturewas reflux for 9 h
3. temperaturecooled down
4. filtrationprecipitate was filtered off
5. washwashed with diethyl ether (10×30 mL) for removal of N-hydroxysuccinimide Precipitate
6. customwas dried under vacuum