Cycloheptylamine → HCID 68748938, compound

HRID 59017Notes

Reaction equation

HRID 59017 reaction equation
[CH:1](=[C:8]1[CH:16](Br)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:19]1([NH2:26])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C1C=CC=CC=1>[CH:1](=[C:8]1[CH:16]([NH:26][CH:19]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2899CycloheptylamineHCID 3081162-Benzylidene-3-bromoindan-1-one

Product 1

HCID 68748938HCID 68748938, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2-Benzylidene-3-bromoindan-1-one 2 (299 mg, 1 mmol) was dissolved in benzene (10 mL). Cycloheptylamine (255 μL, 2 mmol) was added and reaction mixture was stirred for 24 h. Solvent was removed in vacuum and 5 (271 mg, 82%) was isolated as yellow crystals by column chromatography (Hexanes/EtOAc 9:1) followed by crystallization from dichloromethane with pentane.

Workup

  1. customreaction mixture
  2. customSolvent was removed in vacuum

Sources & evidence

ORD record
ord-ec54b695410d4c718897fb0a56166ac3
Source dataset
uspto-grants-2016_09
Patent number
US09439877B2

Reaction notes

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