反应详情

A mixture of 2-oxo-2,3-dihydro-1,3-benzoxazole-6-carbonitrile (Intermediate 6, 220 mg; 1.37 mmol) and aluminium/nickel 1:1 alloy (223.6 mg; 2.61 mmol) in 2.25 ml of formic acid and 0.75 ml of water is stirred at 90° C. for 24 hr. The solid is filtered and washed with ethanol. The filtrate is concentrated in vacuo and dried overnight at 45° C. in a vacuum dessicator. The solid obtained (219 mg; 97% yield) is pure enough as to prosecute with the synthesis.

1. filtrationThe solid is filtered
2. washwashed with ethanol
3. concentrationThe filtrate is concentrated in vacuo
4. customdried overnight at 45° C. in a vacuum dessicator
5. customThe solid obtained (219 mg; 97% yield)
6. customto prosecute with the synthesis