HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(3-Hydroxypropyl)amino]-3-nitrobenzonitrile → 3-Amino-4-((3-hydroxypropyl)amino)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(3-Hydroxypropyl)amino]-3-nitrobenzonitrile | HCID 22349316 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-4-((3-hydroxypropyl)amino)benzonitrile | HCID 22349277 | — |
Reaction Steps
A mixture of 1.12 g (5.06 mmol) of 4-[(3-hydroxypropyl)amino]-3-nitrobenzonitrile (Intermediate 11) and 26.94 mg of 10% Pd on charcoal in 39 ml of EtOH is shaken in an hydrogen atmosphere (14 psi) for 20 hr at rt. After filtration and evaporation 1.012 g of the pure title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09233108B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-7f0fa2850cae41bf99e336d1d9773f8e |
| Source note | uspto-grants-2016_01 |