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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 590455Generated: October 31, 2026

1-Bromo-4-chlorobutane → 9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amine

https://huagongshe.com/reaction/590455

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-chlorobutaneHCID 81364—
ReactantHCID 178456042HCID 178456042—
SolventCyclohexane ethylacetateHCID 21867204—
Product9-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amineHCID 59252648—

Reaction Steps

Prepared similarly to Intermediate 18 from 8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-1H-purin-6-amine trifluoroacetate and 1-bromo-4-chlorobutane with purification on an aminopropyl (NH2) cartridge using a 0-100% ethyl acetate-cyclohexane gradient.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09233962B2
Source datasetuspto-grants-2016_01
ORD IDord-22e6a50dd6b443b7b88759033ee6cd3b
Source noteuspto-grants-2016_01