1-Bromo-4-chlorobutane → HCID 59252640, compound

HRID 590484Notes

Reaction equation

HRID 590484 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15][CH3:16])=[N:13][C:12]2[C:7]1=[N:8][C:9](O[C@@H](C)CC)=[N:10][C:11]=2[NH2:17].FC(F)(F)C(O)=O.[CH3:30][C@@H:31]([NH:35]C1NC2C(N=C(OC)N=2)=C(N)N=1)[CH2:32][CH2:33][CH3:34].BrCCCCCl>>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15][CH3:16])=[N:13][C:12]2[C:7]1=[N:8][C:9]([NH:35][C@H:31]([CH3:30])[CH2:32][CH2:33][CH3:34])=[N:10][C:11]=2[NH2:17]

Participants

4

Reactant 3

HCID 813641-Bromo-4-chlorobutaneHCID 592526489-(4-Chlorobutyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amineHCID 178448279HCID 178448279, compound

Product 1

HCID 59252640HCID 59252640, compound

Procedure

Prepared similarly to Intermediate 44 from N2-[(1R)-1-methylbutyl]-8-(methyloxy)-3H-purine-2,6-diamine trifluoroacetate and 1-bromo-4-chlorobutane.

Sources & evidence

ORD record
ord-31f02849248d437a907e38b760d7cc75
Source dataset
uspto-grants-2016_01
Patent number
US09233962B2

Reaction notes

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