HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 8-(Methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9-[5-(1-piperidinyl)pentyl]-9H-purin-6-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[5-(1-piperidinyl)pentyl]-9H-purin-6-amine | HCID 59252574 | — |
| Reactant | 9-(5-Chloropentyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amine | HCID 59252598 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-(Methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9-[5-(1-piperidinyl)pentyl]-9H-purin-6-amine | HCID 59252646 | — |
Reaction Steps
Prepared similarly to Intermediate 38 from 9-(5-chloropentyl)-8-(methyloxy)-2-{[(1S)-1-methylpropyl]oxy}-9H-purin-6-amine and piperidine but with purification on silica using a 0-25% methanol in dichloromethane gradient.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09233962B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-44c0edc90fb24436a02266d68f389856 |
| Source note | uspto-grants-2016_01 |