Potassium Carbonate → HCID 90025227, compound

Participants

Reaction Steps

5,5-Dimethylcyclohexane-1,3-dione (1.4 g, 10 mmol), 2-bromo-1-(3-bromophenyl)ethanone (2.78 g, 10 mmol) and K2CO3 (1.38 g, 10 mmol) were combined in chloroform (40 mL). The mixture was stirred for 18 hr at room temperature whereupon a white precipitate formed. The solid was collected by filtration, suspended in water and acidified to pH 5 using 1M HCl (aq.). The resulting solid was filtered, washed with water and dried in vacuo to afford the title compound. The aqueous filtrate was evaporated and the crude residue purified on silica gel using a gradient elution of 0-100% ethyl acetate in 40-60 petroleum ether to yield the title product (2.77 g, 82%).

Provenance & Evidence