Isopropanol → HCID 118033097, compound

Participants

Reaction Steps

(E)-2-(2-(3-Bromophenyl)-6,6-dimethyl-6,7-dihydrobenzo[b]thiophen-4(5H)-ylidene)ethyl carbamimidothioate (0.31 g, 0.65 mmol) was suspended in conc. HCl (aq.) (10 mL) and iso-propanol (10 mL) and refluxed for 2 h. Further portions of iso-propanol (5 mL) and conc. HCl (aq.) (15 mL) were added and the mixture was refluxed a further 18 hr. The mixture was cooled in an ice bath and then neutralised with aqueous 2 M NaOH solution. The aqueous layer was then extracted with dichloromethane (×3). The organic phases were combined, dried (MgSO4) and concentrated in vacuo to afford the title compound (0.131 g, 48%).

Provenance & Evidence