HCID 90070457, compound → HCID 90070459, compound

Participants

Reaction Steps

6-(Hydroxymethyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-4-ol (1.2 g, 6.7 mmol) was dissolved in 1,4-dioxane (30 mL) and manganese dioxide (5.8 g, 67 mmol) was added portion-wise at room temperature. The mixture was stirred for 1 h 40 min. The solution was filtered through celite, washed with 1,4-dioxane and concentrated in vacuo. The crude residue was purified on silica gel using a gradient elution of 40-60% ethyl acetate in 40-60 petroleum ether to yield the title compound as a yellow oil (0.745 g, 62%).

Provenance & Evidence