Lawesson's reagent → HCID 90070555, compound

Participants

Reaction Conditions

Reaction Steps

6,7-Dihydro-5H-spiro[benzo[b]thiophene-4,4′-imidazolidine]-2′,5′-dione (0.5 g, 2.25 mmol) and 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's reagent) (0.91 g, 2.25 mmol) were suspended in 1,4-dioxane (5 mL). The mixture was heated by microwave irradiation at 120° C. for 30 min. The solution was concentrated in vacuo and the crude residue purified on silica gel using a gradient elution of 20-100% ethyl acetate in 40-60 petroleum ether. Isolated material was further purified on silica gel using a gradient elution of 2-5% methanol in dichloromethane to afford the title compound as a colourless solid (0.54 g, 100%).

Provenance & Evidence