Benzyl chloroformate → HCID 124008951, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 9b (1.96 g, 7.59 mmol) in THF, Pd/C is added for hydrogenation under a pressure of 35 psi in a par hydrogenator. The reaction mixture was filtered through celite. To the filtrate, saturated NaHCO3 (1.90 g, 22.77 mmol) and CBzCl (1.3 mL, 9.10 mmol) were added and stirred at 25° C. for 5 h. The solvent is removed, 10 mL water is added and the aqueous layer is extracted with EtOAc. The crude mixture is then subjected to column chromatography on silica gel using hexane-DCM mixtures to afford the product 10b as a viscous liquid (1.80 g) in 71% yield.

Provenance & Evidence