Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 3-amino-2-methylpropanoate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Beta-Aminoisobutyric Acid | HCID 64956 | — |
| 생성물 | Methyl 3-amino-2-methylpropanoate hydrochloride | HCID 13063725 | — |
반응 단계
To the solution of DL-3-aminoisobutyric acid (CAS number: 144-90-1, Aldrich) (2.7 g, 26.4 mmol) in MeOH (50 mL) was added SOCl2 (6.17 g, 52.8 mmol) dropwise at 0° C. under N2 atmosphere. The reaction was refluxed for 18 hours. The solvent was removed in vacuo to give crude Compound W which was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09233978B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-3bdec371188e4bf5bf7e54409d90ba2b |
| 출처 메모 | uspto-grants-2016_01 |