Methyl 2-(1-aminocyclopropyl)acetate hydrochloride → 2-[1-[(8aR)-3-oxo-1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyrazin-2yl]cyclopropyl]acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 2-(1-aminocyclopropyl)acetate hydrochloride	HCID 57350660	—
Reactant	(S)-2,2-Dimethyl-3-(3-oxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl)propanoic acid	HCID 118354187	—
Product	2-[1-[(8aR)-3-oxo-1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyrazin-2yl]cyclopropyl]acetic acid	HCID 118354125	—

Reaction Steps

Compound 47-A was prepared in analogy to compound Q in Example 19 by using methyl 2-(1-aminocyclopropyl)acetate hydrochloride salt (for its synthesis, refer to: Sandstroem A., et al, Bioorganic & Medicinal Chemistry, 16(10), 5590-5605; 2008) instead of ethyl 3-amino-2,2-dimethyl-propanoate hydrochloride salt.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09233978B2
Source dataset	uspto-grants-2016_01
ORD ID	ord-2dbaecbd2fba4669bc2354115d9f2d38
Source note	uspto-grants-2016_01