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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 590567Generated: October 31, 2026

(1R,2R)-Ethyl 2-aminocyclopentanecarboxylate → (1R,2R)-2-[(8aS)-3-oxo-1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyrazin-2-yl]cyclopentanecarboxylic acid

https://huagongshe.com/reaction/590567

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1R,2R)-Ethyl 2-aminocyclopentanecarboxylateHCID 6602129—
Reactant(S)-2,2-Dimethyl-3-(3-oxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl)propanoic acidHCID 118354187—
Product(1R,2R)-2-[(8aS)-3-oxo-1,5,6,7,8,8a-hexahydroimidazo[1,5-a]pyrazin-2-yl]cyclopentanecarboxylic acidHCID 118353988—

Reaction Steps

Compound 49-A was prepared in analogy to compound Q in Example 19 by using ethyl (1R,2R)-2-aminocyclopentanecarboxylate (Accela Chembio Co., Ltd, SY024586) instead of ethyl 3-amino-2,2-dimethyl-propanoate hydrochloride salt.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09233978B2
Source datasetuspto-grants-2016_01
ORD IDord-f12c43985cea4603adb8e698fa9af0cc
Source noteuspto-grants-2016_01