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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 590577Generated: October 30, 2026

Ethyl Acetoacetate → Ethyl (S)-6-(bromomethyl)-4-(3-fluoro-2-methylphenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

https://huagongshe.com/reaction/590577

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl AcetoacetateHCID 8868—
Reactant3-Fluoro-2-methylbenzaldehydeHCID 2779235—
ReactantMethyl (R)-6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylateHCID 89995948—
ProductEthyl (S)-6-(bromomethyl)-4-(3-fluoro-2-methylphenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylateHCID 118358767—

Reaction Steps

Compound C-3 was prepared in analogy to compound C by using 2-methyl-3-fluorobenzaldehyde instead of 2-chloro-4-fluorobenzaldehyde and ethyl acetoacetate instead of methyl acetoacetate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09233978B2
Source datasetuspto-grants-2016_01
ORD IDord-0fba235a6d9d44e29861ab470667fefb
Source noteuspto-grants-2016_01