HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → Methyl 6-(bromomethyl)-4-(4-chlorophenyl)-1,4-dihydro-2-(2-thiazolyl)-5-pyrimidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Methyl (R)-6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 89995948 | — |
| Product | Methyl 6-(bromomethyl)-4-(4-chlorophenyl)-1,4-dihydro-2-(2-thiazolyl)-5-pyrimidinecarboxylate | HCID 118354471 | — |
Reaction Steps
Compound C-4 was prepared in analogy to compound C by using 4-chlorobenzaldehyde instead of 2-chloro-4-fluorobenzaldehyde without chiral SFC separation of dihydropyrimidine intermediate in Scheme 1-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09233978B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-9099d8814c304b46826590804ac38ebe |
| Source note | uspto-grants-2016_01 |