Methylamine → 2-Chloro-N-methyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

Participants

Reaction Steps

A solution of methylamine (0.382 mL of 33% solution in absolute ethanol, 3.06 mmol) was added to a solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (200 mg, 0.77 mmol) in acetonitrile (3 mL). The mixture was stirred at ambient temperature for 30 minutes. The solvents was removed in vacuum, and the residue was purified by preparative HPLC to yield the title compound, 135 mg, (69%).

Provenance & Evidence