反应详情

温度

100 °C

A solution of 2,6-diamino-4-hydroxypyrimidine (CAS: 56-06-4, 1 g, 7.93 mmol) and sodium acetate (0.85 g, 10.32 mmol) in water (180 mL) was stirred at 100° C. for 30 minutes. Methyl 4-(2-bromoacetyl)benzoate (2.24 g, 8.72 mmol) was suspended in MeOH (25 mL) and was added slowly to the above solution. The reaction mixture was then stirred at 100° C. for 16-20 h and then cooled to room temperature. The residue was filtered and dried. It was then stirred in CH2Cl2 (10 mL) and filtered to provide XI-8-I (1.07 g, 47.5%). LCMS: m/z 285 (M+1)+.

1. additionwas added slowly to the above solution
2. temperaturecooled to room temperature
3. filtrationThe residue was filtered
4. customdried
5. stirringIt was then stirred in CH2Cl2 (10 mL)
6. filtrationfiltered
7. customto provide XI-8-I (1.07 g, 47.5%)