(2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acid → HCID 11446836, compound

HRID 590674Notes

Reaction equation

HRID 590674 reaction equation
COC(N[C@@H]([C@@H](C)CC)C([N:9]1[C@H:13]([C:14]([OH:16])=[O:15])[CH2:12][C@@H:11]2[CH2:17][CH2:18][CH2:19][C@H:10]12)=O)=O.COC(N[C@@H](C(C)C)C(O)=O)=O>>[NH:9]1[CH:13]([C:14]([OH:16])=[O:15])[CH2:12][CH:11]2[CH2:17][CH2:18][CH2:19][CH:10]12

Participants

3

Reactant 2

HCID 10942966(2S)-2-((methoxycarbonyl)amino)-3-methylbutanoic acidHCID 86723608HCID 86723608, compound

Product 1

HCID 11446836HCID 11446836, compound

Procedure

(2S,3aS,6aS)-1-(S)-2-(methoxycarbonylamino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid was synthesized in a similar manner as (2S,3aS,6aS)-1-((2S,3S)-2-(methoxycarbonylamino)-3-methylpentanoyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid substituting (2S,3S)-2-(methoxycarbonylamino)-3-methylpentanoic acid with (S)-2-(methoxycarbonylamino)-3-methylbutanoic acid. LCMS-ESI+ calc'd for C15H25N2O5: 313.17. Found: 313.12.

Sources & evidence

ORD record
ord-60a9439f678f49ae8183b2cfd69e153b
Source dataset
uspto-grants-2016_01
Patent number
US09233974B2

Reaction notes

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