反应详情

Isopropyl magnesium chloride (0.601 mL, 2M solution, 1.20 mmol) was added dropwise to a solution of 2-chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine-4-carbaldehyde (180 mg, 0.71 mmol) in diethyl ether (10 mL) at −30° C. The mixture was quenched with a saturated aqueous solution of ammonium chloride and then extracted with ethyl acetate (×2). The combined organic phase was dried over sodium sulfate and concentrate. The residue was purified by column chromatography on silica to yield the title compound, 25 mg (12%).

1. customThe mixture was quenched with a saturated aqueous solution of ammonium chloride
2. extractionextracted with ethyl acetate (×2)
3. dry with materialThe combined organic phase was dried over sodium sulfate
4. concentrationconcentrate
5. customThe residue was purified by column chromatography on silica