HCID 118272043, compound → HCID 118272243, compound

Participants

Reaction Steps

The enantiomers of 1-(1-(4-fluorophenyl)-2-methoxyethyl)urea (1.411 g, 6.65 mmol) were separated by SFC (Berger Multigram II SFC, column: Chiral Technology IC-H 2.1×25 cm, 5 uM, mobile phase: 20% to 80% MeOH in CO2(1), flow rate: 70 mL/min, 4 min run time). The fractions were collected and the solvent evaporated in vacuo to afford (S)-1-(1-(4-fluorophenyl)-2-methoxyethyl)urea and (R)-1-(1-(4-fluorophenyl)-2-methoxyethyl)urea. MS ESI calc'd. for C10H13FN2O2 [M+1]+ 213. found 213 (Intermediate 22C) and MS ESI calc'd. for C10H13FN2O2 [M+1]+ 213. found 213 (Intermediate 23C).

Provenance & Evidence