反应详情

To a stirred solution of (3S and R, 4R and S)-1-benzyl-3-nitro-4-phenylpyrrolidine (100 g, 0.354 mol) in methanolic ammonia (1 L) was added Raney Ni (20 g) at room temperature in a 2.0 L hydrogenation flask. The reaction was hydrogenated at 100 psi for 12 h at room temperature. After completion of the reaction, the mixture was filtered through Celite and the filtrate was concentrated in vacuo to afford (3S and R, 4R and S)-1-benzyl-4-phenylpyrrolidin-3-amine, which was carried onto the next step without further purification. MS ESI calc'd. For C17H20N2 [M+1]+ 253. found 253.

1. customAfter completion of the reaction
2. filtrationthe mixture was filtered through Celite
3. concentrationthe filtrate was concentrated in vacuo