2,5-Dimethyloxolan-3-one → HCID 130813445, compound

Participants

Reaction Steps

To a solution of 2,5-dimethyldihydrofuran-3(2H)-one (20 g, 0.175 mol) and NaOAc (43 g, 0.526 mol) in EtOH (300 mL), NH2OH.HCl (15.8 g, 0.228 mol) was added portion in the mixture at 0° C. After addition, the reaction was stirred at rt for 3 h. Filtered, the filtrate was concentrated and the residue was dissolved in DCM, filtered, the filtrate was concentrated to give 2,5-dimethyldihydrofuran-3(2H)-one oxime. 1H NMR (ppm, 300 MHz, CDCl3) δ 3.7-4.9 (m, 2H), 2.0-3.0 (m, 2H), 1.2-1.4 (m, 6H).

Provenance & Evidence