Cesium carbonate → HCID 118271680, compound

Participants

Reaction Conditions

Reaction Steps

6-Chloro-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-amine (5C; 4.0 g, 9.73 mmol), (R)-1-(1-phenylethyl)urea (2.4 g, 14.60 mmol), cesium carbonate (7.9 g, 24.34 mmol) and BrettPhos pre-catalyst (467 mg, 0.584 mmol) were charged in a 350 mL pressure vessel with 1.4-dioxane (88 mL). The system was degassed and stirred at 100° C. for 8 h. The reaction mixture was filtered through Celite, evaporated in vacuo, dissolved in DCM, and purified by flash chromatography (0-20% EtOAc/DCM) to afford (R)-1-(3-amino-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea. MS ESI calc'd. For C34H30N6O2 [M+1]+ 539. found 539.

Provenance & Evidence