Hydrochloric Acid → HCID 117823909, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(((3,3-difluorocyclobutyl)methoxy)methyl)-6-(1-ethoxyvinyl)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)pyrimidin-2-amine (17 mg, 0.04 mmol) in dioxane (3 mL) was added water (0.2 mL) and HCl (9 μL, 0.11 mmol). The mixture was stirred at 50° C. for 20 minutes. The solvents were evaporate and the residue was partitioned between aqueous sodium bicarbonate and DCM. The organic phase was evaporated to give the title compound (16 mg, 100%).

Provenance & Evidence