Trifluoroacetic acid → HCID 118271929, compound

Participants

Reaction Steps

(R)-1-(3-(1,3-Dioxoisoindolin-2-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea (229 mg, 0.342 mmol) was dissolved in DCM (2 mL), charged with TFA (660 μL, 8.56 mmol) and triethylsilane (54.7 μL, 0.342 mmol), and stirred at room temperature for 30 min. The solvents were concentrated in vacuo and the residue was treated with triethylamine (1 mL). Purification via flash chromotagraphy (10-100% EtOAc/DCM) afforded (R)-1-(3-(1,3-dioxoisoindolin-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea. MS ESI calc'd. for C23H18N6O3 [M+1]+ 427. found 427.

Provenance & Evidence