Sodium Acetate → HCID 118271831, compound

Participants

Reaction Steps

A solution of 2-(bromomethyl)-4,6-dichloronicotinonitrile (354.8 mg, 1.334 mmol) in DMF (7 ml) was charged with sodium acetate (198 mg, 2.414 mmol) and stirred at RT for 2 hr. The reaction was quenched with water, extracted twice with Et2O. The organics was washed with brine, dried over MgSO4, filtered and concentrated in vacuo to give (4,6-dichloro-3-cyanopyridin-2-yl)methyl acetate. MS ESI calc'd. For C9H7O2N2O2 [M+I-1]+ 245. found 245.

Provenance & Evidence