Methanol → HCID 118272362, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(bromomethyl)-4,6-dichloronicotinonitrile (378.9 mg, 1.425 mmol) in MeOH (5.0 ml) was charged with silver(I) tetrafluoroborate (360 mg, 1.849 mmol) and stirred at 50° C. for 17 hr. LCMS showed conversion to the desired mass. The mixture was concentrated in vacuo and purified via flash chromatography (15-60% Et2O/Hexane) to provide 4,6-dichloro-2-(methoxymethyl)nicotinonitrile. MS ESI calc'd for C8H7C12N2O [M+H]+ 217. found 217.

Provenance & Evidence