Azetidine → HCID 117820981, compound

Participants

Reaction Steps

To a mixture of azetidine (93 mg, 0.99 mmol) and sodium methoxide (30 wt % in methanol, 0.135 mL, 0.73 mmol) in acetonitrile (6 mL) was added 2,4-dichloro-6-((cyclopropylmethoxy)-methyl)pyrimidine (77 mg, 0.33 mmol). The reaction was stirred at rt for 30 minutes. The mixture was purified by preparative HPLC to give the title compound (44 mg, 53%).

Provenance & Evidence