Cesium carbonate → HCID 131734502, compound

Participants

Reaction Conditions

Reaction Steps

Under inert atmosphere, to a solution of 6-chloro-N,N-bis(4-methoxybenzyl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-amine (0.5 g, 0.77 mmol) in anhydrous 1,4-dioxane (10.0 mL) was added tert-Butyl carbamate (0.26 g, 2.3 mmol), brettphos pre catalyst (0.03 g, 0.004 mmol), Cs2CO3 (0.75 g, 2.3 mmol) and the contents were heated in a sealed tube at 100° C. After 6 h, the reaction mixture was brought back to ambient temperature and the volatiles were removed under reduced pressure. The residue thus obtained was purified by a flash column chromatography to afford the title compound (0.4 g, 71% yield). MS ES calc'd. for C46H45N5O4 [M+H]+ 732. Found 732.

Provenance & Evidence