Isopropylamine → 2-Chloro-N-isopropyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

Participants

Reaction Steps

A solution of isopropylamine (0.10 mL, 1.20 mmol) in MeOH (2 mL) was added dropwise to a ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (104 mg, 0.40 mmol) in acetonitrile (2 mL). The mixture was stirred at rt overnight. The residue was purified by preparative HPLC to give the title compound as a dry film, 63 mg (56%).

Provenance & Evidence