Sodium Sulfate → HCID 117821552, compound

Participants

Reaction Steps

A solution of methanesulfonyl chloride (0.13 mL, 1.64 mmol) in DCM (2 mL) was cooled at −30° C. (2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-yl)methanol (0.35 g, 1.36 mmol) and N,N-diisopropylethylamine (0.45 mL, 2.73 mmol) in DCM (15 mL) were added. The mixture was stirred for 10 min. Brine (50%, 50 mL) was added. The organic phase was isolated using a phase separator containing sodium sulfate. The solvents were evaporated to give the title compound 0.47 g (quant).

Provenance & Evidence