Perchloric Acid → HCID 70855541, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)imidazo[1,2-a]pyridin-3-yl]-2-hydroxyacetate (53 mg, 0.15 mmol) in tert-butyl acetate (4.6 mL) at −20° C. was added perchloric acid (0.6 mL). The mixture was stirred at 0° C. for 2 hours before being poured into a saturated aqueous solution of sodium bicarbonate (10 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2×10 mL). The organic layers were dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate 60/40) to provide the desired product (19d) (38 mg, 0.093 mmol, 57%) as a colorless oil.

Provenance & Evidence