Perchloric Acid → HCID 86717840, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, perchloric acid (70%, 1.9 mL) was added at −10° C. to a solution of methyl (3-bromo-benzo[b]thiophen-2-yl)-hydroxy-acetate (21c) (560 mg, 1.86 mmol) in tertbutyl acetate (15 mL). After 1 hour, the reaction was quenched with a saturated solution of sodium carbonate and extracted with dichloromethane (2×30 mL). The organic layer was washed with brine (20 mL), dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate 95/5) to afford the desired product (21d) as a yellow oil (500 mg, 1.40 mmol, 75%).

Provenance & Evidence