Methanol → HCID 70855549, compound

Participants

Reaction Steps

A solution of (3-bromo-4-methyl-benzo[b]thiophen-2-yl)-hydroxy-acetic acid (23g) (270 mg, 0.9 mmol) and sulfuric acid (500 μL) in methanol (5 mL) was refluxed for 1 hour. The reaction mixture was then concentrated and the residue was diluted with ethyl acetate (20 mL). The organic layer was washed with water (2×20 mL), a saturated aqueous solution of sodium bicarbonate (20 mL), brine (20 mL), dried over sodium sulfate, filtered and evaporated under reduced pressure to afford the desired product (23h) as a orange solid (250 mg, 0.79 mmol, 88%) without further purification.

Provenance & Evidence