Perchloric Acid → HCID 70855555, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, perchloric acid (70%, 1.33 mL) was added at −10° C. to a solution of methyl (3-bromo-4-methyl-benzo[b]thiophen-2-yl)-hydroxy-acetate (23h) (250 mg, 0.79 mmol) in tert-butyl acetate (10 mL). After 1 hour, the reaction was quenched with a saturated aqueous solution of sodium bicarbonate and extracted with dichloromethane (2×30 mL). The organic layer was washed with brine (20 mL), dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel (cyclohexane/ethyl acetate 90/10) to afford the desired product (23i) as a white solid (220 mg, 0.59 mmol, 75%).

Provenance & Evidence