Cyclopropanemethanamine → HCID 117821080, compound

HRID 59104Notes

Reaction equation

HRID 59104 reaction equation
[CH:1]1([CH2:4][NH2:5])[CH2:3][CH2:2]1.[Cl:6][C:7]1[N:12]=[C:11](Cl)[CH:10]=[C:9]([CH2:14][O:15][CH2:16][C:17]([F:20])([F:19])[F:18])[N:8]=1>CO.C(#N)C>[Cl:6][C:7]1[N:12]=[C:11]([NH:5][CH2:4][CH:1]2[CH2:3][CH2:2]2)[CH:10]=[C:9]([CH2:14][O:15][CH2:16][C:17]([F:20])([F:18])[F:19])[N:8]=1

Participants

5

Reactant 2

HCID 75646CyclopropanemethanamineHCID 1178209122,4-Dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

Product 1

HCID 117821080HCID 117821080, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of cyclopropylmethanamine (91 mg, 1.28 mmol) a in MeOH (2 mL) was added to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (111 mg, 0.43 mmol) in acetonitrile (2 mL). The mixture was stirred at ambient temperature overnight. The solution was concentrated and purified by preparative HPLC to give the title compound as a solid, 72 mg (58%).

Workup

  1. concentrationThe solution was concentrated
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-440475bb274d4a3c8be76791c49cb1de
Source dataset
uspto-grants-2016_09
Patent number
US09439904B2

Reaction notes

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