N-bromobutanimide → HCID 70819495, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-(tert-butoxy)-2-{imidazo[1,2-a]pyridin-2-yl}acetate (25c) (108 mg, 0.41 mmol) in ethanol (5 mL) at 0° C. was added N-bromosuccinimide (76 mg, 0.43 mmol) portionwise. The mixture was stirred at 0° C. for 15 minutes and concentrated in vacuo. The residue was dissolved in ethyl acetate (5 mL) and washed with a saturated solution of sodium hydrogencarbonate (2×5 mL). The organic layer was dried over sodium sulfate and concentrated in vacuo to provide the desired product (25d) (127 mg, 0.37 mmol, 90%) as a yellow oil which was used without further purification.

Provenance & Evidence